SIGN 140 Management of primary cutaneous squamous cell carcinoma

Skin cancers are a major and increasing health burden in our ageing population. Cutaneous squamous cell carcinoma (SCC) has increased in incidence by more than 50% in the 10-year period from 2001 to 2011. Whilst many SCC are low-grade and readily treated with surgical excision, there remains an important minority that grow rapidly, are highly invasive and carry a risk of metastasis and death.

This guideline provides recommendations for referral, management and follow up of patients aged 18 years and over with primary invasive SCC. A summary can be viewed here. For the full guideline, visit

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